Katee Jang

Katee Jang

Modified & Updated: 08 Oct 2023

Source: Medstarhealth.org

The human body is a fascinating machine with countless intricate systems and processes. One such system is the endocrine system, which consists of several glands that release hormones into the bloodstream to regulate various bodily functions. One of these glands is the parathyroid gland, responsible for producing parathyroid hormone (PTH). PTH plays a crucial role in maintaining the balance of calcium and phosphorus in the body, which are essential for bone health and proper muscle and nerve function. However, there is much more to PTH than meets the eye. In this article, we will uncover 11 mind-blowing facts about parathyroid hormone, shedding light on its importance and the impact it has on our overall well-being.

Table of Contents

PTH regulates calcium and phosphorus levels in the body.

Parathyroid hormone (PTH) plays a crucial role in maintaining proper levels of calcium and phosphorus in the body. It stimulates the release of calcium from bones, enhances the absorption of calcium in the intestines, and reduces its excretion by the kidneys.

PTH is produced by the parathyroid glands.

The parathyroid glands, located in the neck, are responsible for producing and secreting PTH. These tiny glands work tirelessly to maintain the delicate balance of calcium and phosphorus in the body.

PTH levels vary throughout the day.

PTH secretion follows a diurnal pattern, with higher levels in the early morning and lower levels in the late afternoon and evening. This fluctuation helps regulate calcium homeostasis, ensuring that the body’s needs are met throughout the day.

PTH stimulates the activation of Vitamin D.

PTH stimulates the conversion of inactive Vitamin D into its active form, which is essential for proper calcium absorption in the intestines. This process ensures that the body receives an adequate amount of Vitamin D for optimal bone health.

PTH can cause bone loss.

Excessive levels of PTH can lead to a condition known as hyperparathyroidism, which can result in bone loss. This occurs because PTH promotes the breakdown of bones to release calcium into the bloodstream, potentially leading to weakened bones and an increased risk of fractures.

PTH affects the kidneys.

PTH plays a role in regulating calcium and phosphorus levels in the kidneys. It increases the reabsorption of calcium in the kidneys while decreasing the reabsorption of phosphorus. This helps maintain the balance of these minerals in the body.

PTH influences the functioning of the cardiovascular system.

Studies have shown that PTH levels are associated with cardiovascular health. Higher levels of PTH have been linked to an increased risk of cardiovascular diseases such as hypertension, heart failure, and arterial calcification.

PTH is involved in the formation of new bone tissue.

While excessive PTH levels can lead to bone loss, moderate levels of PTH are necessary for the formation of new bone tissue. PTH stimulates osteoblasts, cells responsible for bone formation, and helps in the remodeling and repair of bones.

PTH affects the functioning of the nervous system.

PTH receptors are found throughout the nervous system, indicating its influence on neuronal function. Studies suggest that PTH may play a role in cognitive function, mood regulation, and neuroprotection.

PTH levels can be measured through blood tests.

Medical professionals can assess PTH levels through blood tests to diagnose various conditions related to calcium and bone metabolism. Abnormal levels of PTH can indicate disorders such as hyperparathyroidism, hypoparathyroidism, or renal dysfunction.

PTH can be targeted for medical treatment.

Pharmaceutical interventions, such as PTH analog medications, can be used to manage conditions like osteoporosis. These analogs mimic the effects of PTH and help improve bone density and reduce the risk of fractures.


In conclusion, the parathyroid hormone (PTH) is a fascinating element of the human anatomy with a multitude of functions and effects. Its role in regulating calcium and phosphorus levels within the body is crucial for maintaining proper bone health and overall bodily function. PTH also plays a vital role in the production of vitamin D, which is essential for calcium absorption. Additionally, this hormone helps regulate blood calcium levels, acting as a thermostat to ensure a balance between bone resorption and bone formation.Understanding the intricacies and functions of PTH is essential for healthcare professionals, researchers, and anyone interested in human anatomy. Its profound impact on our body’s mineral metabolism highlights the complexity of our physiological processes and the remarkable balance that exists within our systems. As research continues, we can look forward to discovering even more mind-blowing facts about PTH and the mechanisms through which it operates.


1. What is the primary function of parathyroid hormone (PTH)?

Parathyroid hormone (PTH) plays a pivotal role in regulating calcium levels in the body. It stimulates the release of stored calcium from bones, increases calcium absorption in the intestines, and enhances the reabsorption of calcium in the kidneys.

2. How is parathyroid hormone (PTH) different from thyroid hormones?

Parathyroid hormone (PTH) is produced in the parathyroid glands, which are separate from the thyroid gland. PTH is responsible for regulating calcium and phosphorus levels, while thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3), regulate the body’s metabolism.

3. Can parathyroid hormone (PTH) levels be too high?

Yes, high levels of parathyroid hormone (PTH) can lead to a condition called hyperparathyroidism. This condition can result in excessive calcium levels in the blood, leading to various symptoms like bone pain, kidney stones, and digestive issues.

4. Are there any conditions associated with low parathyroid hormone (PTH) levels?

Low levels of parathyroid hormone (PTH) can occur in a condition called hypoparathyroidism. It can cause low levels of calcium in the blood, leading to symptoms like muscle cramps, numbness, and tingling in the extremities.

5. Can parathyroid hormone (PTH) levels be measured through blood tests?

Yes, parathyroid hormone (PTH) levels can be measured through a simple blood test. This test helps determine if there are any abnormalities in the levels of PTH, which can aid in diagnosing and managing various parathyroid disorders.

6. Can parathyroid hormone (PTH) be synthesized or produced synthetically?

No, currently, parathyroid hormone (PTH) cannot be synthesized or produced artificially. It is extracted from the parathyroid glands of cadavers for medical use in the form of medications like teriparatide.